Parlodel

Parlodel (Bromocriptine Mesylate) – A Comprehensive Overview

Parlodel, also known as bromocriptine mesylate, is an ergot derivative with potent dopamine receptor agonist activity. This medication is used to treat conditions such as hyperprolactinemia, which is characterized by elevated levels of prolactin in the blood. It works by activating post-synaptic dopamine receptors, thereby inhibiting the secretion of prolactin from the anterior pituitary gland.

Each Parlodel SnapTabs tablet contains 2.5 mg of bromocriptine mesylate, while the capsules contain 5 mg. The active ingredient is chemically designated as Ergotaman-3?,6?,18-trione, 2-bromo-12?-hydroxy-2?-(1-methylethyl)-5?-(2-methylpropyl)-, (5??)-monomethanesulfonate (salt).

The clinical pharmacology of Parlodel involves its role as a dopamine receptor agonist. It significantly reduces plasma levels of prolactin in patients with physiologically elevated prolactin as well as those with hyperprolactinemia. This reduction in prolactin levels can help alleviate symptoms such as galactorrhea (spontaneous milk production) and inhibit physiological lactation.

Parlodel is also used in the treatment of Parkinson’s disease, particularly as an adjunctive therapy to levodopa. It can help manage symptoms like abnormal involuntary movements (dyskinesias) and the marked swings in motor function known as the “on-off” phenomenon. However, the continued efficacy of Parlodel beyond two years has not been established, and its use in newly diagnosed Parkinson’s disease patients is not well-supported by data.

The inactive ingredients in Parlodel tablets include colloidal silicon dioxide, lactose, magnesium stearate, povidone, starch, and another ingredient. The capsules contain colloidal silicon dioxide, gelatin, lactose, magnesium stearate, red iron oxide, silicon dioxide, sodium lauryl sulfate, starch, titanium dioxide, yellow iron oxide, and another ingredient.

Overall, Parlodel is a versatile medication that offers significant benefits for patients with hyperprolactinemia and certain symptoms of Parkinson’s disease. Its mechanism of action and clinical applications make it a valuable addition to treatment regimens for these conditions.