Brexidol 20mg

Brexidol 20mg Piroxicam-?-Cyclodextrin Tablets.

Brexidol 20mg is a non-steroidal anti-inflammatory/analgesic agent designed to provide relief from mild to moderately severe acute pain. It contains piroxicam, a member of the oxicam family of NSAIDs, which is complexed with ?-cyclodextrin to enhance its water solubility and absorption.

Key Features

• Faster Absorption: The complexation with ?-cyclodextrin allows for a faster absorption of the active ingredient, piroxicam, compared to standard piroxicam tablets.
• Comparable Pain Relief: Brexidol provides comparable onset of pain relief to other analgesics like ibuprofen, acetaminophen, and naproxen.
• Pharmacokinetic Parameters: Plasma concentrations of piroxicam following Brexidol administration are proportional for different doses, with a maximum plasma concentration (Cmax) of 2.61 ?g/mL and an area under the plasma concentration-time curve (AUC0-2 hour) of 4.1 ?g/mL*hour.
• Clinical Use: Indicated for the short-term relief of mild to moderately severe acute pain. However, it is recommended to use the lowest effective dose for the shortest possible duration to minimize the risk of cardiovascular or gastrointestinal adverse events.

Important Considerations

• Contraindications and Warnings: Use of Brexidol should be limited in patients with an increased risk of developing cardiovascular and/or gastrointestinal adverse events. Other management strategies that do not include the use of NSAIDs should be considered first.
• Geriatric Use: Evidence suggests that use in the elderly should be cautious due to potential increased sensitivity to NSAIDs.

Brexidol 20mg is a reliable option for managing acute pain, offering enhanced absorption and comparable efficacy to other commonly used analgesics.