Evastin

Avastin (Bevacizumab) – Comprehensive Antineoplastic Agent

Avastin, also known as bevacizumab, is a clear to slightly opalescent, colorless to pale brown, sterile solution for intravenous (IV) infusion. It is available in 100 mg and 400 mg single-dose vials containing 4 mL and 16 mL, respectively, of bevacizumab at a concentration of 25 mg/mL.

What is Avastin Used For?

Avastin is an antineoplastic agent that contains the active ingredient bevacizumab, a recombinant humanized monoclonal antibody. It selectively binds to and neutralizes the biologic activity of human vascular endothelial growth factor (VEGF), which is involved in angiogenesis, the formation of new blood vessels that tumors need to grow.

Indications and Usage

Avastin is indicated for the treatment of several types of cancer, including:

• Metastatic Colorectal Cancer: Used in combination with fluoropyrimidine-based chemotherapy for first- or second-line treatment.
• Non-Squamous Non-Small Cell Lung Cancer: Used with carboplatin and paclitaxel for the first-line treatment of unresectable, locally advanced, recurrent, or metastatic disease.
• Metastatic Breast Cancer: Used with paclitaxel for the treatment of patients who have not received chemotherapy for metastatic HER2-negative breast cancer.

Important Information

Avastin is a sterile solution for IV infusion and is not formulated for intravitreal use. It is supplied in preservative-free, single-use vials. The recommended dosages vary depending on the type of cancer and the treatment regimen.

Side Effects and Precautions

Avastin can cause adverse reactions, and it is essential to follow the recommended dosages and treatment schedules. Discontinuation of Avastin due to adverse reactions occurs in 8.4 to 20.3% of patients across all studies.

Conclusion

Avastin is a powerful antineoplastic agent that has shown effectiveness in treating various types of cancer by inhibiting angiogenesis. It is crucial to consult with a healthcare professional to determine the best course of treatment with Avastin.