Nimbex-100

Nimbex-100: A Reliable Neuromuscular Blocking Agent for Surgical Procedures.

Nimbex-100, also known as cisatracurium besylate, is a non-depolarizing neuromuscular blocking agent used to facilitate tracheal intubation, muscle relaxation during surgery, and mechanical ventilation. This intermediate-duration medication is commonly used in intensive care settings and as an adjunct to general anesthesia.

Cisatracurium besylate works by blocking neuromuscular transmission at the cholinergic receptors, effectively relaxing skeletal muscles. It is administered via intravenous bolus injection and is known for its stable pharmacodynamic profile, with minimal histamine release even at high doses.

The recommended dosage for adults is 0.15 mg/kg, which typically produces good to excellent conditions for tracheal intubation within 120 seconds. For children aged 1 month to 12 years, the initial intubation dose is also 0.15 mg/kg, administered over 5 to 10 seconds. If a shorter clinical duration is required, a dose of 0.1 mg/kg may be used, producing similar intubation conditions at 120 to 150 seconds.

Nimbex-100 is available in a 2 mg/mL solution for injection, without an antimicrobial preservative, and is intended for single-patient use. Monitoring of neuromuscular function is recommended to individualize dosage requirements and ensure optimal muscle relaxation during surgical procedures.

This medication is particularly useful in cardiac surgery and other procedures where muscle relaxation is crucial. Its stable profile and minimal side effects make it a reliable choice for healthcare professionals.