Gliclazide Tab

Gliclazide Tablets: Control High Blood Sugar with Diet and Exercise.

Gliclazide tablets are designed to help manage high blood sugar levels in non-insulin dependent diabetic patients. When used in conjunction with a balanced diet and regular exercise, this medication can effectively control blood sugar levels, reducing the risk of complications such as heart disease, strokes, kidney disease, circulation problems, and blindness.

How to Use

Take Gliclazide tablets with meals to ensure consistent absorption. It is essential to take the medication at the same time each day to maintain a stable blood sugar level.

Medical Uses

Gliclazide is particularly useful for patients whose diabetes cannot be controlled through diet and exercise alone. It is also recommended for those who have already tried metformin without achieving satisfactory results.

Important Considerations

• Type 1 Diabetes: Not suitable for type 1 diabetes.
• Hypersensitivity: Avoid if you are allergic to sulfonylureas.
• Kidney and Liver Issues: Use with caution in severe renal or hepatic failure, but it can be relatively safe in mild renal impairment.

Mechanism of Action

Gliclazide works by binding to the sulfonylurea receptors on the surface of pancreatic beta-cells. This binding action closes the ATP-sensitive potassium channels, leading to a decrease in potassium efflux. This depolarization opens voltage-dependent calcium channels, which activates calmodulin, resulting in the exocytosis of insulin-containing vesicles and the release of insulin.

By enhancing insulin release and improving insulin dynamics, Gliclazide helps to lower blood sugar levels, making it a valuable medication for managing type 2 diabetes effectively.