Methadex

Dexamethasone Tablets for Multiple Myeloma Treatment

Dexamethasone tablets, sold under the brand name HEMADY, are a corticosteroid medication used in combination with other anti-myeloma products to treat adults with multiple myeloma. The recommended dosage is 20 mg or 40 mg, taken orally once daily, on specific days as outlined in the treatment regimen.

Key Features:

• Indication: Treatment of multiple myeloma in adults.
• Dosage: 20 mg or 40 mg orally once daily, depending on the treatment protocol.
• Form: Immediate-release tablets.
• Active Ingredient: Dexamethasone USP.
• Inactive Ingredients: Corn starch NF, lactose monohydrate NF, magnesium stearate NF, povidone NF, and sodium starch glycolate NF.

Important Information:

• Contraindications: Hypersensitivity to dexamethasone and systemic fungal infections.
• Warnings: Potential side effects include HPA axis suppression, Cushing’s syndrome, hyperglycemia, immunosuppression, cardiovascular and renal alterations, venous and arterial thromboembolism, and gastrointestinal perforation.
• Usage Precautions: Avoid live or live attenuated vaccines and use with caution in patients with active or latent peptic ulcers, diverticulitis, fresh intestinal anastomoses, and nonspecific ulcerative colitis.

Pharmacology:

• Mechanism of Action: Dexamethasone has anti-inflammatory effects and low mineralocorticoid activity. It induces apoptosis of multiple myeloma cells.
• Pharmacokinetics: The peak concentration of dexamethasone is reached within 1 hour after a 20 mg dose, with a terminal half-life of approximately 4 hours.

Clinical Use:

Multiple Myeloma Treatment: HEMADY is indicated for the treatment of multiple myeloma in combination with other anti-myeloma products. It helps reduce symptoms such as swelling and allergic-type reactions by decreasing the immune system’s response to various diseases.

By understanding the key features and important information about HEMADY, you can make informed decisions about its use in treating multiple myeloma. Always consult with a healthcare professional for specific guidance on dosage and usage.