Malprate-D

Divalproex Sodium Delayed-Release Tablets: Effective Treatment for Seizures and Migraines

Divalproex sodium delayed-release tablets are a versatile medication used to treat various conditions, including complex partial seizures, simple and complex absence seizures, and migraine headaches. These tablets work by stabilizing electrical activity in the brain, helping to control seizures and alleviate migraine symptoms.

Key Indications:

• Seizures: Divalproex sodium is effective in treating complex partial seizures and simple and complex absence seizures. It can be used as a standalone treatment or in combination with other medications.
• Migraines: The medication is also indicated for the prophylaxis of migraine headaches, helping to reduce the frequency and severity of these episodes.

Dosage Information:

• Mania: The initial dose for treating manic episodes is typically 750 mg daily, which can be increased as needed to achieve therapeutic levels.
• Seizures: For complex partial seizures, the starting dose is usually 10 to 15 mg/kg/day, with adjustments made every week to optimize clinical response. The maximum recommended dosage is 60 mg/kg/day.

Important Contraindications:

• Mitochondrial Disorders: Divalproex sodium is contraindicated in patients known to have mitochondrial disorders caused by POLG mutations.
• Children Under Two: The medication is also contraindicated in children under two years of age who are clinically suspected of having a mitochondrial disorder.

Administration:

Divalproex sodium delayed-release tablets should be taken orally in divided doses. They should be swallowed whole and not crushed or chewed..

Safety Considerations:

• Pancreatitis: If pancreatitis is diagnosed, valproate should be discontinued, and alternative treatment initiated.
• Liver Function: Patients with hepatic disease or significant hepatic dysfunction should use this medication with caution and under close monitoring.

By understanding the indications, dosage, and potential side effects of divalproex sodium delayed-release tablets, you can make informed decisions about your treatment options. Always consult with a healthcare professional before starting any new medication regimen.