Cefbro Inj

Cefuroxime Injection: A Broad-Spectrum Antibiotic for Parenteral Use.

Cefuroxime injection, commonly known as Cefbro Inj, is a semisynthetic, broad-spectrum cephalosporin antibiotic designed for parenteral administration. It is the sodium salt of (6R,7R)-3-carbamoyloxymethyl-7-[Z-2-methoxyimino-2-(fur-2-yl)acetamido]ceph-3-em-4-carboxylate, with the empirical formula C16H15N4NaO8S and a molecular weight of 446.4. Each gram of cefuroxime activity contains approximately 54.2 mg (2.4 mEq) of sodium.

Cefuroxime is highly effective against a wide range of gram-positive and gram-negative organisms, including those resistant to beta-lactamases. It inhibits bacterial cell-wall synthesis, making it a potent bactericidal agent. The drug is detectable in therapeutic concentrations in various bodily fluids, including pleural fluid, joint fluid, bile, sputum, bone, and aqueous humor. It is also detectable in cerebrospinal fluid (CSF) in adults and pediatric patients with meningitis.

The usual adult dosage range for cefuroxime is 750 mg to 1.5 grams every 8 hours, typically for 5 to 10 days. It is commonly used to treat uncomplicated urinary tract infections, skin infections, and other bacterial infections. Cefuroxime is approximately 50% bound to serum protein, which helps maintain its therapeutic levels in the body.

In summary, Cefuroxime Injection is a reliable and versatile antibiotic option for treating a variety of bacterial infections, offering broad-spectrum activity and effective penetration into various bodily fluids. Its stable formulation and well-documented efficacy make it a trusted choice for medical professionals and patients alike.