Clonatril

Clonatril 2 mg is a medication used to treat panic disorder, whether it occurs with or without agoraphobia. Panic disorder is characterized by unexpected panic attacks and the worry about experiencing more of these episodes, along with concerns about their implications or consequences.

Clonatril 2 mg is also indicated for the treatment of Lennox-Gastaut Syndrome, specifically the petit mal variant, akinetic seizures, and myoclonic seizures. It may be considered for patients with absence seizures (petit mal) who have not responded to succinimides.

The long-term effectiveness of Clonatril 2 mg for durations exceeding 9 weeks has not been comprehensively studied in controlled clinical trials. Therefore, physicians who choose to prescribe this medication for extended periods should periodically reassess its long-term suitability for each patient.

Clonatril 2 mg works by reducing nerve transmission in the motor cortex, effectively suppressing spike and wave discharges associated with absence seizures. This mechanism is thought to be linked to its ability to enhance the activity of GABA. In clinical applications, it has proven effective in improving both focal epilepsy and generalized seizures.

Dosage Information

For Adults with Seizure Disorders:

• Begin with 1.5 mg per day, divided into three doses..
• Adjust by 0.5-1 mg every three days, up to a maximum of 20 mg per day..

For Adults with Panic Disorder:

• Start with 0.25 mg twice daily..
• After three days, increase to 1 mg per day as needed..

For Pediatric Patients:

To minimize drowsiness, infants and children (up to 10 years or 30 kg) should take 0.01-0.03 mg/kg/day, not exceeding 0.05 mg/kg/day, split into multiple doses..

Important Considerations

Clonatril 2 mg shares pharmacological properties common to benzodiazepines, encompassing anticonvulsive, sedative, muscle-relaxing, and anxiolytic effects. The central actions of benzodiazepines involve enhancing GABAergic neurotransmission at inhibitory synapses. Animal studies also indicate that this medication may affect serotonin levels.

In infants and young children, the use of Clonatril 2 mg may lead to increased saliva and bronchial secretions. Therefore, it is essential to ensure clear airways.

Clonatril 2 mg offers beneficial effects in both generalized and focal epilepsies. However, its long-term use should be monitored closely due to potential habit-forming properties and the need for periodic reassessment of its suitability for each patient.