Losamide

Lacosamide: Effective Seizure Control for Partial-Onset and Generalized Tonic-Clonic Seizures

Lacosamide is an antiepileptic medication designed to help manage partial-onset seizures and primary generalized tonic-clonic seizures. It works by blocking certain sodium channels in the brain, which helps reduce the frequency and severity of seizures.

Key Information

• Indications: Lacosamide is indicated for the treatment of partial-onset seizures in children and adults. It is also used as an adjunctive therapy for primary generalized tonic-clonic seizures in patients four years of age and older.
• Dosage Forms: Available in tablet, solution, and extended-release capsule forms.
• Mechanism of Action: Lacosamide targets voltage-gated sodium channels, specifically inhibiting the alpha subunits of sodium channels, which helps control seizure activity.
• Absorption: The medication is completely absorbed after oral administration with a high absolute bioavailability of approximately 100%. Food does not affect the rate and extent of absorption, and steady-state plasma concentrations are achieved after three days of twice-daily administration.

Important Considerations

• Prescription Required: Lacosamide is available only with a doctor’s prescription.
• Dosage: The extended-release capsules are indicated for the treatment of partial-onset seizures in adults and pediatric patients weighing at least 50 kg.
• Analgesic Activity: Lacosamide has been shown to possess analgesic activity by blocking sensory neuronal voltage-gated sodium channels that mediate neuropathic pain responses.

By understanding how Lacosamide works and its various forms, you can better manage your seizures and improve your quality of life. Always consult with your healthcare provider for personalized advice on using this medication.