Rimactal 450mg

Rimactal 450mg Tablet – Effective Treatment for Tuberculosis

Rimactal 450mg is a powerful combination of two essential antituberculosis medications: Rifampicin and Isoniazid. This fixed-dose combination is specifically designed to stop the growth of mycobacteria, which cause tuberculosis. It is used for the continuation phase of tuberculosis treatment, ensuring that the infection is fully managed and reduced.

Key Features

• Active Ingredients: Rifampicin 450mg and Isoniazid 300mg.
• Therapeutic Class: Combined Anti-Tubercular Preparations.
• Indications: Used for the continuation phase of tuberculosis treatment.
• Pharmacology: Both Rifampicin and Isoniazid are active bactericidal agents that target rapidly growing extracellular organisms and have intracellular activity. Rifampicin inhibits DNA-dependent RNA polymerase in susceptible cells, while Isoniazid acts against actively growing tubercle bacilli.

Dosage and Administration

• Body Weight <50 kg: 3 tablets of 150/100 mg once daily or 1 tablet of 450/300 mg once daily.
• Body Weight >50 kg: 2 tablets of 300/150 mg once daily.
• Hepatic Impairment: Maximum dose is 8 mg/kg daily.

Important Considerations

• Interactions: May reduce the effectiveness of hormonal contraceptives and decrease plasma concentrations of certain antivirals. Reduced absorption with antacids.
• Contraindications: Known or suspected hypersensitivity to rifamycins and/or isoniazid, acute liver diseases, peripheral neuritis, and a history of drug-induced hepatitis.

Side Effects

• Common Side Effects: Asymptomatic increase in liver enzymes, reddish discoloration of body fluids, nausea, abdominal pains, vomiting or diarrhea, pseudomembranous colitis, tiredness, drowsiness, headache, dizziness, ataxia, mental confusion, muscular weakness, visual disturbances, leucopenia, eosinophilia, thrombocytopenia, and thrombocytopenic purpura.
• Rare but Serious Side Effects: Severe life-threatening hepatic reactions, hepatic failure, acute fulminant hepatitis, renal insufficiency, haemolysis, haematuria, interstitial nephritis, and exfoliative dermatitis.

Pregnancy and Lactation

Pregnancy Category C: Animal studies have shown adverse effects on the fetus. There are no adequate and well-controlled studies in humans, but the potential benefits may warrant use despite the risks.

Rimactal 450mg is a reliable and effective treatment option for tuberculosis, ensuring that patients receive the necessary medication to manage and reduce the infection. Always consult with a healthcare provider before starting any new medication.