Safdroxil

Cefadroxil Monohydrate – Effective Antibiotic for Oral Use

Cefadroxil monohydrate is a semisynthetic cephalosporin antibiotic designed for oral administration. It is a white to yellowish-white crystalline powder that is soluble in water and stable in acidic conditions. Chemically, it is designated as 5-Thia-1-azabicyclo [4.2.0]oct-2-ene-2-carboxylic acid, 7-[[amino(4-hydroxyphenyl)acetyl]amino]-3-methyl-8-oxo-, monohydrate, [6R-[6?,7?(R*)]]. It has the formula C16H17N3O5S•H2O and a molecular weight of 381.40.

Our cefadroxil monohydrate is available in film-coated tablets, each containing 1 gram of the active ingredient. The inactive ingredients include microcrystalline cellulose, hydroxypropyl methylcellulose, magnesium stearate, polyethylene glycol, and polysorbate 80.

Uses:

• Streptococcal Pharyngitis and Tonsillitis: Effective against streptococcal infections of the throat and tonsils.
• Bronchopneumonia and Bacterial Pneumonia: Treats bacterial pneumonia, including bronchopneumonia.
• Uncomplicated Urinary Tract Infections: Helps manage pyelonephritis and cystitis.
• Skin and Soft Tissue Infections: Treats abscesses, furunculosis, impetigo, erysipelas, pyoderma, and lymphadenitis.

Mechanism of Action:

Cefadroxil works by inhibiting bacterial cell wall synthesis. It binds to one or more penicillin-binding proteins, leading to the formation of a defective cell wall that is osmotically unstable, causing bacterial cell lysis.

Resistance:

While cefadroxil may be active against some beta-lactamase-producing organisms, it is inactivated by beta-lactamases that efficiently hydrolyze cephalosporins, such as extended-spectrum beta-lactamases and chromosomal cephalosporinases like AmpC type enzymes.

Dosage:

The maximum daily dosage is 4 grams. For chronic urinary tract infections, prolonged and intensive treatment may be required, with continued susceptibility testing.

By choosing cefadroxil monohydrate, you can effectively manage a variety of bacterial infections, ensuring you receive the right treatment for your needs.