Selcarb

Sevelamer Carbonate Tablets for Hyperphosphatemia Control

Sevelamer carbonate tablets are designed to help manage high phosphorus levels in the blood, particularly in patients with chronic kidney disease (CKD) who are on dialysis or not on dialysis with serum phosphorus levels above 1.78 mmol/L. These tablets work by binding to phosphate in the gastrointestinal tract, preventing its absorption and thereby lowering serum phosphorus levels.

Key Indications:

• Adults on Dialysis: For controlling hyperphosphatemia in adult patients receiving haemodialysis or peritoneal dialysis.
• Adults with CKD: For controlling hyperphosphatemia in adult patients with chronic kidney disease not on dialysis.
• Pediatric Patients: For controlling hyperphosphatemia in pediatric patients aged 6 years and older with chronic kidney disease, provided they have a body surface area (BSA) of at least 0.75 m².

Dosage and Administration:

• The starting dose is 0.8 or 1.6 grams administered orally three times a day with meals, based on serum phosphorus levels for adults and body surface area for pediatric patients..
• Titration can be done every two weeks as needed to achieve the desired serum phosphorus target..

Mechanism of Action:

Sevelamer carbonate is a non-absorbed phosphate-binding cross-linked polymer that interacts with phosphate molecules through ionic and hydrogen bonding in the intestine, effectively reducing phosphate absorption and lowering serum phosphorus levels.

Benefits:

• Helps control hyperphosphatemia, which can lead to weaker bones and other complications..
• Part of a comprehensive treatment approach that may include calcium supplements and Vitamin D analogues to manage renal bone disease..

Product Details:

Each film-coated tablet contains 800 mg of sevelamer carbonate. The inactive ingredients include ammonium hydroxide, colloidal silicon dioxide, crospovidone, hydroxypropyl cellulose, lecithin, mannitol, polyvinyl alcohol, propylene glycol, shellac, talc, xanthan gum, and zinc stearate. The tablet imprint contains iron oxide black ink.

By using sevelamer carbonate tablets, patients can help manage their hyperphosphatemia effectively, contributing to better overall health management. Always consult with a healthcare provider for proper dosing and treatment guidance.