Profenid

Profenid E 100 mg: Effective Relief for Musculoskeletal and Joint Disorders

Profenid E 100 mg is a non-steroidal anti-inflammatory drug (NSAID) designed to provide symptomatic relief for various musculoskeletal and joint disorders. It is indicated for conditions such as ankylosing spondylitis, osteoarthritis, and rheumatoid arthritis. Additionally, it is effective in managing periarticular disorders like bursitis and tendinitis, as well as mild to moderate pain associated with dysmenorrhea or postoperative pain.

Profenid E 100 mg is also used to control pain and inflammation in acute gout and soft tissue disorders. The medication is available in different forms, including tablets, SR capsules, and an IM injection, which is particularly useful for managing acute exacerbations of rheumatoid arthritis, osteoarthritis, and ankylosing spondylitis.

Therapeutic Class

• Drugs for Osteoarthritis.
• Drugs used for Rheumatoid Arthritis.
• Non-steroidal Anti-inflammatory Drugs (NSAIDs).

Pharmacology

Profenid E 100 mg works by inhibiting the synthesis of prostaglandins, which are key mediators of inflammation and pain. It also stabilizes lysosomal membranes and inhibits leukotriene synthesis, contributing to its anti-inflammatory effects. The drug is rapidly absorbed from the GI tract and is approximately 99% bound to plasma protein, mainly albumin. It is extensively metabolized in the liver, primarily through conjugation with glucuronic acid, and is excreted mainly in the urine.

Dosage & Administration

• Oral Treatment: 50-100 mg daily, taken with food to minimize gastrointestinal disturbance. For rheumatic diseases, 100-200 mg daily in 2-4 divided doses with food. For pain and dysmenorrhea, 50 mg up to 3 times daily.
• SR Capsules: 100-200 mg once daily, depending on patient’s weight and severity of symptoms.
• IM Injection: Adults: 50 to 100 mg every four hours, repeated up to a maximum of 200 mg in twenty-four hours for up to 3 days. Following a satisfactory response, oral therapy should be instituted with Profenid E 100 mg tablets.
• Elderly: Begin therapy at the lower end of the dose range and maintain patients on the lowest effective dosage.
• Pediatric Dosage: Not established for intramuscular use.
• Topical Gel: Apply to the painful area twice daily. The gel can be used with an occlusive dressing and rubbed gently into the skin to ensure penetration.
• Suppository: 1 suppository (100 mg) late at night, supplemented as required with Profenid E 100 mg capsules during daytime.

Uses

Profenid E 100 mg is indicated for the symptomatic treatment of acute and chronic rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, primary dysmenorrhea, and mild to moderate pain associated with musculotendinous trauma (sprains and strains), postoperative (including dental surgery) or postpartum pain.