Zaclazide

Gliclazide (Diamicron) 30mg Tablets for Type 2 Diabetes Management

Gliclazide, sold under the brand name Diamicron, is a sulfonylurea medication used to treat type 2 diabetes. It works by stimulating the pancreas to release more insulin, which helps lower blood sugar levels. This medication is particularly useful for patients who cannot control their diabetes through diet and exercise alone, and it is often prescribed after metformin has been tried.

Key Features:

• Mechanism of Action: Gliclazide binds to the sulfonylurea receptors (SUR-1) on pancreatic beta-cells, blocking potassium channels and leading to cell depolarization. This opens calcium channels, increasing calcium influx, which triggers the release of insulin-containing vesicles.
• Absorption: Gliclazide is rapidly absorbed after oral administration, with peak plasma concentrations occurring within 4-6 hours.
• Metabolism: It is extensively metabolized in the liver, with less than 1% of the dose appearing unchanged in the urine.
• Half-Life: The duration of action is approximately 10-24 hours, with a half-life of 10.4 hours.
• Contraindications: Gliclazide is not suitable for patients with type 1 diabetes, hypersensitivity to sulfonylureas, severe renal or hepatic failure, or pregnancy and lactation.

Benefits:

• Improved Insulin Sensitivity: Gliclazide enhances peripheral insulin sensitivity, helping to manage blood sugar levels more effectively.
• Cardiovascular Protection: It provides cardiovascular protection by not binding to sulfonylurea receptors in the heart, reducing the risk of cardiovascular complications.

Product Information:

• Formulation: Diamicron 30mg tablets are a modified release formulation, designed to provide sustained action and improved efficacy.
• Excipients: The tablets contain calcium hydrogen phosphate, maltodextrin, hypromellose, magnesium stearate, and silica colloidal anhydrous.

Gliclazide is a reliable option for managing type 2 diabetes, offering a combination of effective insulin secretion and cardiovascular protection. If you have any questions or need further information, please consult your healthcare provider or pharmacist.